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Application to epidemiological record data in a large-scale biobank (Tohoku Medical Megabank Organization, Japan) shows that a combination of kurPCA and RAMP effectively detects known errors or inconsistent patterns. Read more here.
https://www.lupop.lu.se/article/outlier-detection-questionnaire-data-biobanks - 2025-12-14
Socioeconomic status has a negative impact on swimming ability in Swedish children, a new BlueHealth study has found. Read more here.
https://www.lupop.lu.se/article/new-study-highlights-disparity-swimming-skills - 2025-12-14
A pan-European enterprise to provide a catalogue (https://bio.tools) of tools and databases that can be used in these workflows. bio.tools not only lists where to find resources, but also provides a wide variety of practical information. Read more here.
https://www.lupop.lu.se/article/biotools-registry-software-tools-and-data-resources-life-sciences - 2025-12-14
This Glossary, rooted primarily in the Canadian context but drawing on lessons from elsewhere, describes environmental public health regulatory practice in relation to health equity, including approaches that practitioners can use to contribute to addressing the social determinants of health. Read more here.
https://www.lupop.lu.se/article/glossary-health-equity-context-environmental-public-health-practice - 2025-12-14
Mediation analysis is a powerful tool for understanding mechanisms, but conclusions about direct and indirect effects will be invalid if there is unmeasured confounding of the mediator–outcome relationship. Read more here.
https://www.lupop.lu.se/article/approximate-sensitivity-analysis-unmeasured-mediator-outcome-confounding - 2025-12-14
Over the past decade, several large registries of patients with idiopathic pulmonary fibrosis (IPF) have been established. These registries are collecting a wealth of longitudinal data on thousands of patients with this rare disease. The data collected in these registries will be complementary to data collected in clinical trials because the patient populations studied in registries have a broader
https://www.lupop.lu.se/article/patient-registries-idiopathic-pulmonary-fibrosis - 2025-12-14
The Hamburg City Health Study (HCHS) is a large, prospective, long-term, population-based cohort study and a unique research platform and network to obtain substantial knowledge about several important risk and prognostic factors in major chronic diseases. A random sample of 45,000 participants between 45 and 74 years of age from the general population of Hamburg, Germany, are taking part in an ex
https://www.lupop.lu.se/article/rationale-and-design-hamburg-city-health-study - 2025-12-14
Surgical quality registries are important tools for both performing research and improving clinical practice. The Swedish National Knee Ligament Registry (SNKLR) has collected patient-reported and surgical data on more than 90% of the anterior cruciate ligament (ACL) reconstructions in Sweden. There has year-by-year been an increasing number of publications using data from SNKLR and the Scandinavi
Self-selection into prospective cohort studies and loss to follow-up can cause biased exposure-outcome association estimates. Previous investigations illustrated that such biases can be small in large prospective cohort studies. The structural approach to selection bias shows that general statements about bias are not possible for studies that investigate multiple exposures and outcomes, and that
https://www.lupop.lu.se/article/bias-self-selection-and-loss-follow-prospective-cohort-studies - 2025-12-14
Comorbidity in stroke is common, but comprehensive reports are sparse. We describe prevalence of comorbidity and the prognostic impact on mortality and functional outcome in a large national ischemic stroke cohort. New publication in SAGE Journals
Multiple asthma patient registries have been established globally to provide valuable information on current clinical management, including treatment patterns, adherence, and the long-term outcomes that are important to patients, providers, and other decision makers. New publication in Immunology
https://www.lupop.lu.se/article/step-right-direction-harmonizing-measures-use-asthma-patient-registries - 2025-12-14
An increasing number of patients with central nervous system (CNS) tumor could survive to reproductive age. However, it is largely unknown whether the history of CNS tumor might affect pregnancy outcome. We aimed to explore the risk of being born preterm among children of CNS tumor survivors. New publication in International Journal of Cancer
To inform evidence-based practice in health care, guidelines and policies require accurate identification, collation, and integration of all available evidence in a comprehensive, meaningful, and time-efficient manner. Approaches to evidence synthesis such as carefully conducted systematic reviews and meta-analyses are essential tools to summarize specific topics. Unfortunately, not all systematic
Nu finns ett nytt nyhetsbrev från SND att läsa online, med bland annat ledare av Monica Lassi vid LU. Läs nyhetsbrevet här.
https://www.lupop.lu.se/article/natverksnytt-fran-snd - 2025-12-14
The European Society of cardiology (ESC) EURObservational Research Programme (EORP) Chronic Ischemic Cardiovascular Disease registry Long Term (CICD) aims to study the clinical profile, treatment modalities and outcomes of patients diagnosed with CICD in a contemporary environment in order to assess whether these patients at high cardiovascular risk are treated according to ESC guidelines on preve
Real-world data, such as patient registries, are important for health surveillance purposes and for informed decision making, especially in case of diseases whose rarity reduces the feasibility of trials and makes information difficult to collect. New publication in Value in Health
https://www.lupop.lu.se/article/value-rare-disease-registry-italian-region-friuli-venezia-giulia - 2025-12-14
In this issue, Weiss discusses “generalizing” inferences from randomized trials to other populations. However, he does not explicitly define what “generalizing” means, assumes that “generalizing” the results of a randomized trial has a single goal, and reduces generalizability to a binary subjective judgment—findings are either generalizable or not generalizable. New publication in European Journa
https://www.lupop.lu.se/article/extending-inferences-randomized-trial-target-population - 2025-12-14
The influence of gender on bipolar disorder is controversial and it is unclear if inpatient care differs between men and women. Here, we investigate for gender differences in the inpatient length of stay for Swedes admitted for bipolar disorder and explore other factors that could explain any observed association. New publication in Journal of Affective Disorders
When analyzing effect heterogeneity, the researcher commonly opts for stratification or a regression model with interactions. While these methods provide valuable insights, their usefulness can be somewhat limited, since they typically fail to take into account heterogeneity with respect to many dimensions simultaneously, or give rise to models with complex appearances. New publication in European
https://www.lupop.lu.se/article/assessing-heterogeneous-effects-and-their-determinants-estimation-potential-outcomes - 2025-12-14
Data on the 4466 trauma patients in the registry were analysed. Out of 59 variables, most (n = 51; 86.4%) were missing less than 20% of observations. There were 808 (18.1%) patients missing at least one of the first in-hospital physiological observations. Hospital death was associated with missing in-hospital physiological data (adjusted OR 1.4; 95% CI 1.02–2.01; p = 0.04). New publication in Worl
https://www.lupop.lu.se/article/establishing-multicentre-trauma-registry-india-evaluation-data-completeness - 2025-12-14
